Monitoring Oseltamivir-Resistant H1N1 Virus in Japan
Author Information
Author(s): Ujike Makoto, Ejima Miho, Anraku Akane, Shimabukuro Kozue, Obuchi Masatsugu, Kishida Noriko, Hong Xu, Takashita Emi, Fujisaki Seiichiro, Yamashita Kazuyo, Horikawa Hiroshi, Kato Yumiko, Oguchi Akio, Fujita Nobuyuki, Tashiro Masato, Odagiri Takato
Primary Institution: National Institute of Infectious Diseases, Tokyo, Japan
Hypothesis
To monitor and characterize oseltamivir-resistant (OR) pandemic (H1N1) 2009 virus with the H275Y mutation.
Conclusion
No evidence of sustained spread of oseltamivir-resistant pandemic (H1N1) 2009 was found in Japan, but two suspected incidents of human-to-human transmission were reported.
Supporting Evidence
- 61 oseltamivir-resistant viruses were detected out of 4,307 specimens.
- Most cases of OR pandemic (H1N1) 2009 emerged sporadically from oseltamivir-sensitive viruses.
- Two suspected cases of human-to-human transmission were reported.
Takeaway
Researchers looked at a lot of samples from sick people to see if a certain flu virus was resistant to a medicine. They found some resistant viruses but not many people were spreading them to each other.
Methodology
Analyzed 4,307 clinical specimens from Japan by neuraminidase sequencing or inhibition assay.
Limitations
The study may not capture all cases due to the sporadic nature of the resistant virus and reliance on clinical specimens.
Participant Demographics
Of 61 case-patients with OR viruses, 36 (59%) were male; age distribution included 31% aged 0–4 years, 41% aged 5–18 years, 20% aged 19–50 years, and 8% aged over 50 years.
Digital Object Identifier (DOI)
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