The Emergence and Fate of Horizontally Acquired Genes in Escherichia coli
Author Information
Author(s): Mark W. J. van Passel, Pradeep Reddy Marri, Howard Ochman
Primary Institution: University of Arizona
Hypothesis
How do horizontally acquired genes evolve and persist in Escherichia coli?
Conclusion
The study finds that while horizontally acquired genes (HOPs) are gained more frequently, ORFan genes are more likely to persist over time.
Supporting Evidence
- HOPs are acquired more frequently but are less likely to persist than ORFans.
- Shigella species show significantly lower retention rates of acquired genes compared to E. coli strains.
- ORFans constitute between 9% and 14% of the protein coding genes per genome.
Takeaway
Bacteria can gain and lose genes over time, and some new genes stick around longer than others. This study looks at how this happens in E. coli.
Methodology
The study analyzed the gene content of 13 sequenced strains of E. coli and Shigella to assess the distribution and ancestry of acquired genes.
Potential Biases
Potential biases may arise from the selection of strains and the methods used for gene identification.
Limitations
The study focuses only on a limited number of strains and may not represent all E. coli or Shigella species.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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