Hypermethylation of ribosomal DNA in human breast carcinoma
2000
Ribosomal DNA Methylation in Breast Cancer
Sample size: 58
publication
Evidence: moderate
Author Information
Author(s): Yan P S, Rodriguez F J, Laux D E, Perry M R, Standiford S B, Huang T H-M
Primary Institution: University of Missouri
Hypothesis
Is ribosomal DNA methylation a useful marker for breast cancer progression?
Conclusion
Ribosomal DNA methylation is significantly higher in breast tumors compared to normal samples and is associated with certain tumor characteristics.
Supporting Evidence
- The mean percent of methylation was significantly higher in breast tumors than in normal control samples.
- Increased rDNA methylation was associated with oestrogen receptor non-expression.
- Higher rDNA methylation was linked to moderately or poorly differentiated tumors compared to well differentiated tumors.
Takeaway
This study found that breast cancer cells have more methylation in their ribosomal DNA than normal cells, which could help doctors track how the cancer is changing.
Methodology
Examined the methylation status of ribosomal DNA in breast cancer patients.
Participant Demographics
Patients with breast cancer.
Statistical Information
P-Value
p<0.0001, p<0.0273, p<0.0475
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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