Gitelman-like syndrome after cisplatin therapy: a case report and literature review
2006
Gitelman-like syndrome after cisplatin therapy: a case report
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Panichpisal Kessarin, Angulo-Pernett Freddy, Selhi Sharmila, Nugent Kenneth M
Primary Institution: Texas Tech University Health Sciences Center
Hypothesis
Can cisplatin therapy lead to Gitelman-like syndrome and chronic electrolyte abnormalities?
Conclusion
Cisplatin can cause permanent nephrotoxicity, including Gitelman-like syndrome.
Supporting Evidence
- Only thirteen other patients with similar electrolyte abnormalities have been described in the literature.
- This case has the longest follow-up of 20 years after cisplatin therapy.
- The patient required daily treatment to maintain her electrolyte levels.
- Laboratory results were consistent with a diagnosis of Gitelman's syndrome.
Takeaway
A woman developed a rare condition after cancer treatment that caused her body to lose important minerals, making her feel very tired and weak.
Methodology
Case report and literature review.
Limitations
Only one case is reported, limiting generalizability.
Participant Demographics
One 42-year-old woman with a history of ovarian cancer.
Digital Object Identifier (DOI)
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