Gene Variants and Body Mass Index Changes in Young Adults
Author Information
Author(s): Ramakrishnan Lakshmy, Sachdev Harshpal S, Sharma Meenakshi, Abraham Ransi, Prakash Swami, Gupta Dileep, Singh Yogendra, Bhaskar Seema, Sinha Shikha, Chandak Giriraj R, Reddy Kolli S, Santosh Bhargava
Primary Institution: All India Institute of Medical Sciences, New Delhi, India
Hypothesis
How do gene variants in APOA5, PPARĪ³, and hepatic lipase affect body mass index and coronary artery disease risk factors from childhood to young adulthood?
Conclusion
The study found that certain gene variants are associated with higher triglyceride and HDL2 levels, but not with significant changes in body mass index from childhood to adulthood.
Supporting Evidence
- The risk allele of APOA5 was associated with 23.6 mg/dl higher triglycerides.
- The risk allele of HL was linked to significantly higher HDL2 levels.
- No significant associations were found between gene polymorphisms and BMI changes from birth to adulthood.
Takeaway
Some genes can affect how much fat is in your blood, but they don't really change how much you grow from being a kid to an adult.
Methodology
The study analyzed gene polymorphisms in a cohort of 1492 subjects using PCR and assessed their association with lipid levels and BMI changes over time.
Limitations
The study did not capture current dietary intake and physical activity, which may influence lipid levels.
Participant Demographics
The cohort consisted of individuals from the New Delhi Birth Cohort, primarily Indian, with a mix of genders and socio-economic backgrounds.
Statistical Information
P-Value
p < 0.001 for APOA5, p = 0.002 for HL
Confidence Interval
95% CI 16.0 to 31.2 for APOA5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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