Maternal Markers for Early-Onset Neonatal Infection in Premature Rupture of Membranes
Author Information
Author(s): Thomas Popowski, François Goffinet, Françoise Maillard, Thomas Schmitz, Sandrine Leroy, Gilles Kayem
Primary Institution: Epidemiological Research Unit on Perinatal and Women's Health, INSERM U953, Paris, France
Hypothesis
The study aims to investigate the predictive value of maternal biological markers for early-onset neonatal infection and maternal chorioamnionitis in women with premature rupture of membranes at or after 34 weeks of gestation.
Conclusion
C-reactive protein at admission is the most accurate marker for predicting early-onset neonatal infection in women with premature rupture of membranes.
Supporting Evidence
- 4.3% of newborns had early-onset neonatal infection.
- 5.3% of women had clinical chorioamnionitis.
- C-reactive protein was significantly associated with early-onset neonatal infection.
- The prediction model had an area under the ROC curve of 0.82.
Takeaway
Doctors can use a blood test for C-reactive protein to help decide if a pregnant woman with a broken water bag needs immediate delivery or can wait safely.
Methodology
A two-center prospective study analyzing maternal serum and vaginal markers in women with premature rupture of membranes at or after 34 weeks of gestation.
Potential Biases
Potential bias related to the management strategies employed at the two centers.
Limitations
The study may have limitations due to the systematic active management approach used in one center.
Participant Demographics
Women with premature rupture of membranes at or after 34 weeks of gestation, mean age 31.7 years.
Statistical Information
P-Value
1.0
Confidence Interval
[0.72, 0.92]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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