Smoking and COX-2 Polymorphisms Increase Gastric Cancer Risk
Author Information
Author(s): Zhang Xue-Mei, Zhong Rong, Liu Li, Wang Ying, Yuan Ju-Xiang, Wang Peng, Sun Chuang, Zhang Zhi, Song Wen-Guang, Miao Xiao-Ping
Primary Institution: Ministry of Education Key Lab of Environment and Health, Tongji Medical College, Huazhong University of Science and Technology
Hypothesis
The study aimed to explore the interaction between smoking and functional polymorphisms of COX-2 in modulation of gastric cardia adenocarcinoma (GCA) risk.
Conclusion
The functional polymorphisms of COX-2, in interaction with smoking, may play a substantial role in the development of gastric cardia adenocarcinoma.
Supporting Evidence
- Smokers had a 1.8 fold increased risk of GCA compared to non-smokers.
- The –1195AA genotype was associated with a 1.50 increased risk of GCA.
- The –765GC genotype conferred a 2.06 fold increased risk of GCA.
- The 587Gly/Arg genotype was associated with a 1.67 fold increased risk of GCA.
Takeaway
This study found that certain genetic variations in a cancer-related gene, when combined with smoking, can increase the risk of a specific type of stomach cancer.
Methodology
A case-control study was conducted with genotyping of three COX-2 polymorphisms in 357 GCA patients and 985 controls, followed by multivariate logistic regression analysis.
Potential Biases
Potential selection bias in the recruitment of controls and cases.
Limitations
The study was limited to a specific population (Han Chinese) and may not be generalizable to other ethnic groups.
Participant Demographics
Participants were unrelated Han Chinese individuals, including 357 GCA patients and 985 cancer-free controls, matched by sex and age.
Statistical Information
P-Value
0.006
Confidence Interval
95% CI 1.05–2.13
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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