Preoperative Injection of OK-432 for Gastric Cancer
Author Information
Author(s): Gochi A, Orita K, Fuchimoto S, Tanaka N, Ogawa N
Primary Institution: Okayama University Medical School
Hypothesis
The study investigates the prognostic significance of augmenting tumor-infiltrating lymphocytes (TILs) through preoperative intratumoral injection of OK-432 in gastric cancer patients.
Conclusion
The study found that preoperative injection of OK-432 can effectively reduce regional lymph node metastasis in gastric cancer patients with positive TILs.
Supporting Evidence
- OK-432 significantly increased the 5- and 10-year survival rates of patients with stage IIIA + IIIB, moderate lymph node metastasis.
- The OK-432 it group with positive TILs showed a significant decrease in metastatic lymph node frequency.
- Preoperative intratumoral injection of OK-432 is technically very easy and has no serious adverse effects.
Takeaway
Giving a special treatment called OK-432 before surgery can help some stomach cancer patients have fewer problems with cancer spreading to their lymph nodes.
Methodology
Patients were randomized into an OK-432 group and a control group, with follow-up for 10 years post-surgery.
Limitations
The overall survival rates were not significantly higher for the OK-432 group compared to the control group.
Participant Demographics
Patients with gastric cancer who underwent curative resection.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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