Oseltamivir and Its Impact on Influenza Resistance in Sewage Treatment
Author Information
Author(s): Fick Jerker, Lindberg Richard H., Tysklind Mats, Haemig Paul D., Waldenström Jonas, Wallensten Anders, Olsen Björn
Primary Institution: Umeå University
Hypothesis
Does oseltamivir persist in sewage treatment and contribute to the development of drug resistance in influenza A virus?
Conclusion
Oseltamivir is not removed during normal sewage treatment, which may lead to environmental drug resistance in influenza A virus.
Supporting Evidence
- The active form of oseltamivir is not removed in sewage treatment.
- Environmental residues of oseltamivir may lead to drug-resistance in influenza A virus.
- Oseltamivir is widely used for treating influenza, raising concerns about resistance.
Takeaway
The medicine oseltamivir doesn't get cleaned out of sewage water, which could help the flu virus become resistant to it.
Methodology
Batch experiments simulating normal sewage treatment were conducted to assess the fate of oseltamivir.
Limitations
The study primarily focuses on the fate of oseltamivir in sewage treatment without considering other environmental factors.
Digital Object Identifier (DOI)
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