Epidemiologic application of verbal autopsy to investigate the high occurrence of cancer along Huai River Basin, China
2011

Cancer Rates and Water Pollution in Huai River Basin, China

Sample size: 3301 publication Evidence: high

Author Information

Author(s): Wan Xia, Zhou Maigeng, Tao Zhuang, Ding Ding, Yang Gonghuan

Primary Institution: Institute of Basic Medical Sciences of Chinese Academy of Medical Sciences

Hypothesis

Are cancer prevalence and mortality rates significantly higher in villages along the Huai River due to water pollution?

Conclusion

Cancer mortality rates were much higher in the study areas near the Huai River compared to control areas.

Supporting Evidence

  • The annual average SMRs of cancer in the study areas were 277.8/100,000 and 223.6/100,000.
  • Cancer mortality fractions were 48% in S County and 44% in Y District.
  • The prevalence rates of cancer were significantly higher in the study areas compared to control areas.

Takeaway

This study found that people living near the Huai River, where the water is polluted, get cancer more often than those living in cleaner areas.

Methodology

The study compared death rates and causes of death between polluted and non-polluted areas using verbal autopsy.

Potential Biases

Potential recall bias due to the retrospective nature of the study.

Limitations

The study's retrospective design may introduce recall bias, and the long questionnaire could affect operability.

Participant Demographics

Deaths included individuals aged 5 years and older, with a focus on cancer cases.

Statistical Information

P-Value

p<0.05

Confidence Interval

95% CI for SMR: (252.4, 303.2) for S County; (201.9, 245.3) for Y District

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1478-7954-9-37

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