Antimicrobial Activity of Ruta angustifolia Against Periodontal Pathogen
Author Information
Author(s): Bakri Husna Hazirah, Syed Abdul Rahman Syarifah Nur, Dol Bakri Zarith Safinaz, Munadziroh Elly, Wan Harun Wan Himratul Aznita
Primary Institution: Department of Oral & Craniofacial Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia
Hypothesis
Extracts of R. angustifolia exhibit significant antimicrobial activity against P. gingivalis.
Conclusion
Extracts of R. angustifolia have the potential to be used as an alternative treatment in addition to conventional periodontal therapies.
Supporting Evidence
- The chloroform fractionated extract of R. angustifolia showed the highest inhibition zones against P. gingivalis.
- The MIC and MBC of the chloroform fractionated extract were determined to be 6.25 mg/mL.
- Biofilm biomass was reduced by up to 91% with the highest concentration of the extract.
Takeaway
This study found that a plant called Ruta angustifolia can help fight a harmful bacteria that causes gum disease.
Methodology
The study evaluated the antimicrobial activity of R. angustifolia extracts using well diffusion, MIC, MBC, biofilm biomass assessment, and FE-SEM.
Limitations
The study primarily focused on P. gingivalis and may not reflect the effects on other oral microorganisms.
Statistical Information
P-Value
6.25 mg/mL
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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