Chem(Pro)2: The Atlas of Chemoproteomic Probes Labelling Human Proteins
Author Information
Author(s): Fu Songsen, Chen Zhen, Luo Zhiming, Nie Meiyun, Fu Tingting, Zhou Ying, Yang Qingxia, Zhu Feng, Ni Feng
Primary Institution: Ningbo University
Hypothesis
The study aims to develop a comprehensive database of chemoproteomic probes (CPPs) that label human proteins in living cells.
Conclusion
The Chem(Pro)2 database provides a unique and systematic collection of diverse types of CPPs that can label human proteins, facilitating drug discovery and target identification.
Supporting Evidence
- Chem(Pro)2 includes 603 CPPs and 14,250 binding proteins.
- The database is open to all users without any login requirement.
- Data were collected from 118 living cell types across 22 healthy/disease organs.
- Chem(Pro)2 provides detailed chemical data and experimental details for each CPP.
- The database is expected to facilitate AI-based learning for drug discovery.
Takeaway
This study created a big database that helps scientists find out how different chemicals interact with human proteins, which can help in making new medicines.
Methodology
The database was developed through literature reviews and experimental validation of CPPs, competitors, and their interactions with human proteins.
Limitations
The study may not cover all possible CPPs and their interactions due to the limitations of existing databases and the complexity of biological systems.
Digital Object Identifier (DOI)
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