Association Between Serum Antinuclear Antibody and Polycystic Ovarian Syndrome in Women Aged 18 to 35
Author Information
Author(s): Muacevic Alexander, Adler John R, Shrivastava Chandrashekhar, Sagiraju Praharshitha, Rajbhar Sarita, Bansal Ruchi, Kodumuri Loukya
Primary Institution: All India Institute of Medical Sciences, Raipur, IND
Hypothesis
Is there a relationship between antinuclear antibody positivity and polycystic ovarian syndrome (PCOS) in women aged 18 to 35?
Conclusion
The study found an increased prevalence of antinuclear antibody positivity in women with PCOS compared to controls, but no statistically significant association was established.
Supporting Evidence
- The prevalence of ANA positivity in PCOS was found to be 10%, compared to 4.3% in controls.
- No significant association was found between ANA positivity and PCOS.
- Significant differences were noted in clinical and hormonal parameters between PCOS and control groups.
Takeaway
The study looked at whether women with a condition called PCOS have more antibodies in their blood that might suggest an autoimmune issue, and found that they do, but it wasn't a strong link.
Methodology
This cross-sectional study involved 140 women aged 18-35, divided into PCOS and control groups, with clinical examinations and blood tests for ANA estimation.
Limitations
The study's small sample size may limit the generalizability of the findings, and its cross-sectional design does not allow for establishing causality.
Participant Demographics
Women aged 18-35, with 70 diagnosed with PCOS and 70 healthy controls.
Statistical Information
P-Value
0.326
Statistical Significance
p=0.326
Digital Object Identifier (DOI)
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