Six Types of Multistability in a Neuronal Model Based on Slow Calcium Current
2011
Six Types of Multistability in a Neuronal Model Based on Slow Calcium Current
publication
Evidence: moderate
Author Information
Author(s): Malashchenko Tatiana, Shilnikov Andrey, Cymbalyuk Gennady
Primary Institution: Georgia State University
Hypothesis
What are the bio-physical mechanisms underlying different types of co-existence of oscillatory and silent regimes in a neuronal model?
Conclusion
The study developed a neuronal model that exhibits a rich variety of different types of multistability.
Supporting Evidence
- The model shows six types of multistability: tonic spiking and hyperpolarized silence, tonic spiking and subthreshold oscillations, tonic spiking and bursting, bursting and subthreshold oscillations, bursting and hyperpolarized silence, and bursting, subthreshold oscillations, and silence.
- The study provides a unique opportunity to study the dynamics of networks with neurons possessing different types of multistability.
- The mechanisms supporting multistability are not well understood or classified, highlighting a gap in current knowledge.
Takeaway
This study shows that neurons can switch between different types of activity, like being quiet or bursting with activity, depending on certain conditions.
Methodology
A low-dimensional model of a leech heart interneuron was developed and analyzed using bifurcation analysis.
Digital Object Identifier (DOI)
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