Treatment of Malignant Hypercalcaemia with Aminohexane Bisphosphonate
Author Information
Author(s): N.P. O'Rourke, E.V. McCloskey, S. Rosini, R.E. Coleman, J.A. Kanis
Primary Institution: University of Sheffield, UK
Hypothesis
Can aminohexane bisphosphonate effectively treat hypercalcaemia due to malignancy?
Conclusion
Aminohexane bisphosphonate is effective in treating tumor-induced hypercalcaemia with rapid onset and low toxicity.
Supporting Evidence
- All 20 patients experienced a fall in serum calcium after treatment.
- 65% of patients achieved normocalcaemia.
- The treatment was associated with a significant decrease in fasting urinary calcium excretion.
Takeaway
This study shows that a medicine called aminohexane bisphosphonate can help lower high calcium levels in cancer patients, and it doesn't make people feel very sick.
Methodology
Twenty patients with hypercalcaemia were treated with a single infusion of 125 mg of aminohexane bisphosphonate, and serum and urine biochemistry were measured before and after treatment.
Limitations
The follow-up numbers were low for some time points, and eight patients died within 28 days of treatment.
Participant Demographics
10 men and 10 women, mean age 61.3 years, with various types of malignancies.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.001
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