The function of APC/CCdh1 in cell cycle and beyond
2009
The Role of APC/Cdh1 in Cell Cycle Regulation
publication
Evidence: high
Author Information
Author(s): Li Min, Zhang Pumin
Primary Institution: Baylor College of Medicine
Hypothesis
APC/Cdh1 plays essential roles in regulating the cell cycle and other cellular processes.
Conclusion
APC/Cdh1 is crucial for maintaining proper cell cycle transitions and has broader implications beyond mitosis.
Supporting Evidence
- APC/Cdh1 is essential for preventing premature S phase entry.
- Cdh1-deficient cells can still proliferate but accumulate mitotic errors.
- APC/Cdh1 is involved in the regulation of neural functions and learning.
Takeaway
APC/Cdh1 helps control when cells divide and can also affect other important functions in the body.
Methodology
This review summarizes current understanding of APC/Cdh1 function based on various studies.
Digital Object Identifier (DOI)
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