Gonadotropins Increase p120 in Rat Ovaries
Author Information
Author(s): Yoshino Miki, Mizutani Tetsuya, Yamada Kazuya, Yazawa Takashi, Ogata-Kawata Hiroko, Sekiguchi Toshio, Kajitani Takashi, Miyamoto Kaoru
Primary Institution: Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Japan
Hypothesis
Does the co-activator p120 enhance progesterone receptor activity in the rat ovary when induced by gonadotropins?
Conclusion
The study suggests that p120 is induced in ovarian granulosa cells and may enhance progesterone receptor activity to promote ovulation.
Supporting Evidence
- p120 was strongly expressed in the ovary and testis.
- PMSG treatment increased p120 expression in vivo.
- p120 co-localized with progesterone receptors in large antral follicles.
- p120 activated multiple steroid hormone receptors in transfection experiments.
- Expression patterns of p120 and progesterone receptor were similar during follicular development.
Takeaway
This study found that a protein called p120 helps the ovary work better when hormones are present, which is important for making eggs.
Methodology
The study involved cloning the p120 gene, examining its expression in the ovary, and conducting co-transfection experiments to assess its function as a co-activator.
Participant Demographics
Immature Wistar female rats (21 days old)
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website