Deletions in the Amelogenin Gene in Indian Males
Author Information
Author(s): Kashyap VK, Sahoo Sanghamitra, Sitalaximi T, Trivedi R
Primary Institution: National DNA Analysis Centre, Central Forensic Science Laboratory, Kolkata, INDIA
Hypothesis
Are there deletions in the Y-derived amelogenin gene fragment among Indian males?
Conclusion
The study found that the use of certain amelogenin primer sets may lead to incorrect gender identification due to undetected mutations.
Supporting Evidence
- The failure rate among Indian males was found to be 0.23%.
- Deletions were absent among Mongoloid tribes of Northeast India.
- The study suggests that the mutations could be lineage-specific, particularly in the J2 Y-chromosomal lineage.
Takeaway
Some Indian men have a part of their DNA that can make gender tests fail, which means they might be wrongly identified as women.
Methodology
DNA samples were analyzed using commercial genetic profiling kits and newly designed primers to identify mutations.
Limitations
The exact size and nature of the deletion could not be determined.
Participant Demographics
Participants included 4,257 males from 104 different endogamous populations across India.
Digital Object Identifier (DOI)
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