HPV and Chromosomal Abnormalities in Cervical Lesions
Author Information
Author(s): Giannoudis A, Evans M F, Southern S A, Herrington C S
Primary Institution: Department of Pathology, University of Liverpool, Royal Liverpool University Hospital
Hypothesis
Is basal keratinocyte tetrasomy in low-grade cervical lesions restricted to high and intermediate risk HPV infections?
Conclusion
Tetrasomy in basal keratinocytes is associated with high and intermediate risk HPV infections but is not specific to any HPV type.
Supporting Evidence
- Tetrasomy was found in basal keratinocytes infected with high risk and intermediate risk HPVs.
- No tetrasomy was identified in epithelia infected with low risk HPVs.
Takeaway
This study found that certain types of HPV can cause extra chromosomes in skin cells in the cervix, but not all HPV types do this.
Methodology
The study analyzed 179 low-grade cervical squamous intra-epithelial lesions and 15 normal cervices for HPV presence using PCR and in situ hybridization.
Digital Object Identifier (DOI)
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