RepeatsDB in 2025: Expanding Annotations of Structured Tandem Repeats Proteins
Author Information
Author(s): Clementel Damiano, Arrías Paula Nazarena, Mozaffari Soroush, Osmanli Zarifa, Castro Ximena Aixa, Borucki Estefanía Lorena, Cabrera Maia, Chinestrad Patricio, Czarnowski Ian, Lombardo Jose Francisco, Menna Pablo Lorenzano, Mogro Ezequiel Gerardo, Padilla Franzotti Carla Luciana, Santillan Julia Yamila, Ferrari Carlo, Kajava Andrey V, Tosatto Silvio C E, Monzon Alexander Miguel
Primary Institution: University of Padova
Conclusion
The updated RepeatsDB significantly enhances the classification and annotation of structured tandem repeat proteins, increasing the number of unique protein sequences annotated by fifteenfold.
Supporting Evidence
- RepeatsDB now features annotations for over 34,000 unique protein sequences from more than 2,000 organisms.
- The database has improved detection of structured tandem repeat proteins using advanced structural alignment tools.
- A new user interface enhances the browsing experience and data accessibility.
Takeaway
RepeatsDB is like a big library that helps scientists understand special proteins that repeat their shapes. This new version has a lot more information to help researchers find what they need.
Methodology
The database incorporates data from the Protein Data Bank and AlphaFoldDB, utilizing structural alignment tools and community curation for annotation.
Digital Object Identifier (DOI)
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