Effect of Hachimijiogan on Kidney Function and HIF-1α
Author Information
Author(s): Oka Hiroshi, Goto Hirozo, Koizumi Keiichi, Nakamura Shin, Tsuneyama Koichi, Zhou Yue, Jo Michiko, Fujimoto Takako, Sakurai Hiroaki, Shibahara Naotoshi, Saiki Ikuo, Shimada Yutaka
Primary Institution: University of Toyama
Hypothesis
Does hachimijiogan improve renal function and influence HIF-1α levels in a remnant kidney model?
Conclusion
Hachimijiogan has a protective effect on renal function through the activation of HIF-1α.
Supporting Evidence
- Hachimijiogan reduced urinary protein excretion in treated rats.
- HIF-1α levels increased in the renal cortex of rats treated with hachimijiogan.
- VEGF and glucose transporter 1 mRNA levels were elevated in the high-dose hachimijiogan group.
- Urinary 8-OHdG levels were significantly lower in the hachimijiogan group compared to the control group.
Takeaway
Hachimijiogan, a traditional Japanese medicine, helps protect the kidneys by boosting a protein that helps cells survive low oxygen.
Methodology
The study used 50 male Sprague-Dawley rats, with 40 undergoing 5/6 nephrectomy and divided into treatment groups receiving hachimijiogan or candesartan.
Potential Biases
Potential bias in the selection of treatment doses and the animal model used.
Limitations
The study was limited to a short treatment duration and a specific animal model.
Participant Demographics
50 male Sprague-Dawley rats, aged 6 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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