How Proton Pump Inhibitors Affect Immune Cells
Author Information
Author(s): Fowler Josef F., Eubank Taryn A., Garey Kevin W.
Primary Institution: College of Pharmacy, University of Houston, Houston, TX, United States
Hypothesis
The study aims to determine how proton pump inhibitors (PPIs) inhibit macrophage and neutrophil function, potentially increasing infection risk.
Conclusion
Proton pump inhibitors can impair the function of immune cells, which may lead to an increased risk of infections.
Supporting Evidence
- PPIs have been shown to influence macrophage and neutrophil function.
- Long-term use of PPIs is associated with increased rates of infectious diseases.
- PPIs inhibit the generation of reactive oxygen species in neutrophils.
Takeaway
Proton pump inhibitors, which are common medications, can make your immune cells less effective, possibly leading to more infections.
Methodology
A systematic review of studies investigating the effects of PPIs on macrophage and neutrophil function was conducted using databases like Scopus and PubMed.
Potential Biases
Potential bias in study selection and publication bias due to the exclusion of non-English articles.
Limitations
The review may not cover all relevant studies and focuses only on English-language articles.
Participant Demographics
The studies included healthy adult participants and various sample sizes.
Digital Object Identifier (DOI)
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