Major ozonated autohemotherapy promoted functional recovery following spinal cord injury in adult rats via the inhibition of oxidative stress and inflammation
2024

Ozonated Autohemotherapy Helps Rats Recover from Spinal Cord Injury

Sample size: 54 publication 10 minutes Evidence: moderate

Author Information

Author(s): Xia Liwei, Sun Yongming, Zhou Yue, Yang Qian, Huang Jianhan

Primary Institution: The Second Affiliated Hospital of Soochow University

Hypothesis

Can major ozonated autohemotherapy (MOA) improve recovery following spinal cord injury in rats?

Conclusion

MOA treatment significantly improved locomotor and bladder function in rats after spinal cord injury.

Supporting Evidence

  • Rats treated with MOA showed improved locomotor scores on multiple days post-injury.
  • MOA treatment reduced residual urine volumes significantly compared to the SCI group.
  • Histological analyses indicated less tissue damage in MOA-treated rats.

Takeaway

This study shows that a special blood treatment using ozone can help rats walk better after hurting their spines.

Methodology

Rats were divided into groups and treated with MOA, followed by assessments of locomotor and bladder function.

Potential Biases

Potential bias in behavioral assessments due to subjective scoring.

Limitations

The study was conducted on rats, and results may not directly translate to humans.

Participant Demographics

54 female Sprague-Dawley rats.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1515/biol-2022-1004

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