SCOWLP: A Database for Protein Interfaces
Author Information
Author(s): Teyra Joan, Doms Andreas, Schroeder Michael, Pisabarro M Teresa
Primary Institution: Department of Bioinformatics, BIOTEC TU Dresden
Hypothesis
The study aims to develop a comprehensive database that includes detailed information about protein interfaces, including interactions with ligands and solvent.
Conclusion
SCOWLP significantly enhances the understanding of protein interfaces by incorporating detailed information about peptidic-ligands and solvent interactions.
Supporting Evidence
- SCOWLP includes 74,907 protein interfaces and 2,093,976 residue-residue interactions.
- The database allows detailed structural analysis and comparisons of protein interfaces at atomic level.
- SCOWLP is automatically updated with every SCOP release.
Takeaway
SCOWLP is a tool that helps scientists see how proteins interact with each other and with other small molecules, making it easier to understand how they work.
Methodology
The SCOWLP database was created by extracting 3D data from the PDB and defining protein domains from SCOP, using algorithms to compute interactions at atomic, residue, and domain levels.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website