DNA Repair Gene Variants and Bladder Cancer Risk
Author Information
Author(s): Sak Sei Chung, Barrett Jennifer H, Paul Alan B, Bishop D Timothy, Kiltie Anne E
Primary Institution: Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK
Hypothesis
Do polymorphisms in the XRCC1 gene influence the risk of bladder cancer?
Conclusion
The study found no evidence of an association between XRCC1 polymorphisms and bladder cancer risk, although there may be a modestly increased risk for carriers of the Arg280His variant.
Supporting Evidence
- The study analyzed 14 XRCC1 polymorphisms in a case-control design.
- No polymorphism showed a significant association with bladder cancer risk at the 5% level.
- The Arg280His variant was marginally associated with increased bladder cancer risk in current smokers.
Takeaway
This study looked at how certain gene changes might affect the risk of getting bladder cancer, but it didn't find a strong link.
Methodology
A case-control study analyzing 14 XRCC1 polymorphisms in over 1100 subjects.
Potential Biases
Recall bias for smoking, occupational exposure, and family history cannot be excluded.
Limitations
The study had limited power to detect associations for low frequency variants and potential selection bias due to the control groups used.
Participant Demographics
Majority of subjects were Caucasian (98.6%), with a mean age of 72.8 years for cases and 71.9 years for controls.
Statistical Information
P-Value
0.06
Confidence Interval
1.50 [0.98–2.28]
Statistical Significance
p=0.06
Digital Object Identifier (DOI)
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