Induction of apoptosis by the ADEPT agent ZD2767: comparison with the classical nitrogen mustard chlorambucil and a monofunctional ZD2767 analogue
2001
Induction of Apoptosis by ZD2767 Compared to Chlorambucil
publication
Author Information
Author(s): Monks N R, Blakey D C, Curtin N J, East S J, Heuze A, Newell D R
Primary Institution: Cancer Research Unit, University of Newcastle upon Tyne
Hypothesis
The study aims to identify the mode of cell death induced by ZD2767P + CPG2 in comparison to chlorambucil.
Conclusion
The study demonstrated that ZD2767 induces apoptosis at levels similar to chlorambucil, but with different characteristics.
Supporting Evidence
- ZD2767P is a prodrug that generates an active drug targeting tumors.
- Apoptosis was measured using three different methods, showing consistent results.
- Both ZD2767P + CPG2 and chlorambucil induced apoptosis in a concentration and time-dependent manner.
Takeaway
This study found that a new drug called ZD2767 can make cancer cells die in a similar way to an older drug called chlorambucil.
Methodology
Apoptosis in LoVo tumour cells was studied using nuclear morphology, annexin V staining, and TUNEL assays.
Digital Object Identifier (DOI)
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