Mandibular Osteomas in Cancer Families
Author Information
Author(s): J.O. S0ndergaard, L.B. Svendsen, I.N. Witt, S. Bullow, K.B. Lauritsen, G. Tetens
Primary Institution: Hvidovre Hospital and Bispebjerg Hospital, Copenhagen, Denmark
Hypothesis
The occurrence of small mandibular osteomas represents one of perhaps many yet undiscovered markers common to the aetiology of colorectal cancer.
Conclusion
The study found that mandibular osteomas are present in a significant percentage of members of cancer families, suggesting a potential genetic link.
Supporting Evidence
- 8 out of 31 CFS members had osteomas, which is 26%.
- 3 of 5 CFS patients studied had osteomas.
- Earlier studies showed 76% of FPC patients had osteomas compared to about 5% in the normal population.
Takeaway
This study looked at family members with a history of cancer and found that many had small growths in their jaws, which might be a sign of a genetic risk for cancer.
Methodology
Orthopantomography of the mandible was performed on family members, and findings were supplemented with intraoral X-rays.
Limitations
The study's control group consisted of patients with different medical issues, which may not provide a direct comparison.
Participant Demographics
31 members from two Danish cancer families, including 14 males and 17 females with a median age of 34 years.
Statistical Information
Confidence Interval
95% confidence limits: 12-45
Want to read the original?
Access the complete publication on the publisher's website