DCC expression is related to mucinous differentiation but not changes in expression of p21WAF1/Cip1 and p27Kip1, apoptosis, cell proliferation and human papillomavirus infection in uterine cervical adenocarcinomas
1999
DCC Expression and Mucinous Differentiation in Cervical Adenocarcinomas
Sample size: 80
publication
Author Information
Author(s): Saegusa M, Okayasu I
Primary Institution: Department of Pathology, Kitasato University School of Medicine
Hypothesis
To clarify possible roles of DCC expression in tumour differentiation and cell kinetics.
Conclusion
DCC expression in cervical adenocarcinomas is closely associated with mucinous differentiation.
Supporting Evidence
- DCC scores were significantly decreased in endometrioid adenocarcinomas compared to normal cervical tissues.
- Higher p21WAF1/Cip1 and p27Kip1 scores were found in endometrioid adenocarcinomas than in mucinous adenocarcinomas.
- No relationship was found between DCC expression and cell kinetic markers or HPV status.
Takeaway
The study looked at how a protein called DCC relates to different types of cervical cancer, finding that it is linked to mucinous cancer types.
Methodology
Immunohistochemical investigation of 80 cervical adenocarcinomas and comparison with normal samples and various assays.
Participant Demographics
80 uterine cervical adenocarcinomas, including 31 mucinous and 31 endometrioid lesions.
Digital Object Identifier (DOI)
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