Bunyamwera Serogroup Viruses and Human Congenital Defects
Author Information
Author(s): Charles H. Calisher, John L. Sever
Primary Institution: Colorado State University, Fort Collins, Colorado, USA; George Washington University Medical Center, Children's National Medical Center, Washington, D.C., USA
Hypothesis
Are Bunyamwera serogroup viruses associated with human congenital defects of the central nervous system?
Conclusion
The study provides evidence that Bunyamwera serogroup viruses may be linked to certain congenital defects in humans.
Supporting Evidence
- Antibody to Cache Valley virus was significantly correlated with macrocephaly in infants.
- Presence of antibody to TEN virus was correlated with microcephaly.
- Samples were collected from a large archival collection of serum specimens.
Takeaway
Scientists looked at blood samples from mothers of babies with head size problems to see if certain viruses might be causing these issues.
Methodology
Serum samples from mothers of children with microcephaly or macrocephaly were tested for neutralizing antibodies to Bunyamwera serogroup viruses.
Potential Biases
The presence of antibodies does not necessarily indicate causation of congenital defects, as infections could have occurred before pregnancy.
Limitations
The sample sizes were relatively small, and the study is considered preliminary.
Participant Demographics
Mothers of children with microcephaly or macrocephaly, matched by age and location.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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