Chemopotentiation of CCNU metabolites by misonidazole
1985
Enhancing the Effectiveness of CCNU with Misonidazole
publication
Evidence: moderate
Author Information
Author(s): R.T. Mulcahy
Primary Institution: University of Rochester
Hypothesis
Can Misonidazole enhance the cytotoxicity of CCNU metabolites?
Conclusion
Misonidazole significantly enhances the cytotoxicity of CCNU metabolites in vitro.
Supporting Evidence
- Misonidazole enhances the cytotoxicity of CCNU metabolites.
- Cis-4-OH CCNU is more toxic than CCNU.
- Cis-2-OH CCNU is less effective than CCNU.
- All four isomers' cytotoxicity is significantly enhanced with Misonidazole.
Takeaway
This study shows that a drug called Misonidazole can make another drug, CCNU, work better against cancer cells.
Methodology
EMT-6/Ro tumor cells were treated in vitro with Misonidazole and various hydroxylated metabolites of CCNU under hypoxic conditions.
Statistical Information
P-Value
p<0.01
Confidence Interval
1.2-1.4, 1.8-2.2, 1.7-1.9, 1.6-1.9
Statistical Significance
p<0.05
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