Expression of multiple cancer-testis antigen genes in gastrointestinal and breast carcinomas
2001
Cancer-Testis Antigens in Gastrointestinal and Breast Cancers
publication
Author Information
Author(s): Mashino K, Sadanaga N, Tanaka F, Yamaguchi H, Nagashima H, Inoue H, Sugimachi K, Mori M
Primary Institution: Medical Institute of Bioregulation, Kyushu University
Hypothesis
The study investigates the expression of specific cancer-testis antigen genes in gastrointestinal and breast carcinomas.
Conclusion
The study identifies several cancer-testis antigens that may be promising candidates for cancer-specific immunotherapy.
Supporting Evidence
- SCP-1 was expressed in 23.5% of gastric carcinoma samples.
- LAGE-1 was expressed in 39.1% of oesophageal carcinoma samples.
- SCP-1 was expressed in 34.1% of breast carcinoma samples.
- Frequent synchronous expression of MAGE with other antigens was observed.
Takeaway
Some genes that are usually only found in testis are also found in certain cancers, which could help create better cancer treatments.
Methodology
The expression of 6 cancer-testis antigen genes was investigated using reverse transcription-polymerase chain reaction in surgical samples.
Digital Object Identifier (DOI)
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