Discovery of New Simian Hemorrhagic Fever Viruses in Wild Monkeys
Author Information
Author(s): Michael Lauck, David Hyeroba, Alex Tumukunde, Geoffrey Weny, Simon M. Lank, Colin A. Chapman, David H. O'Connor, Thomas C. Friedrich, Tony L. Goldberg
Primary Institution: University of Wisconsin-Madison
Hypothesis
What are the genetic characteristics of novel simian hemorrhagic fever virus variants found in wild primates?
Conclusion
This study documents the first discovery of simian hemorrhagic fever virus in a wild primate and reveals significant genetic diversity among the variants.
Supporting Evidence
- The study identified two novel SHFV variants co-infecting a single wild monkey.
- Both new variants showed high genetic divergence from each other and from the type strain.
- This research expands knowledge of the natural history and diversity of arteriviruses.
Takeaway
Scientists found two new types of a virus in a wild monkey in Uganda, showing that wild animals can carry viruses that might be dangerous.
Methodology
The viruses were detected directly from blood plasma using direct pyrosequencing without prior virus isolation.
Limitations
The study is limited by the single sample size and the potential for underestimating diversity due to limited genome sequences available for comparison.
Participant Demographics
A single male red colobus monkey from Kibale National Park, Uganda.
Digital Object Identifier (DOI)
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