Role of survivin and its splice variants in tumorigenesis
2005
Role of survivin and its splice variants in tumorigenesis
publication
Evidence: moderate
Author Information
Author(s): Li F
Primary Institution: Roswell Park Cancer Institute
Hypothesis
Survivin and its splice variants play a differential role in tumorigenesis.
Conclusion
Survivin and its variants may have distinct roles in tumor development and progression.
Supporting Evidence
- Survivin is highly expressed in cancer but undetectable in normal adult tissues.
- Loss of survivin-2B expression is associated with later stages of cancer development.
- Survivin expression correlates with lower apoptotic indices and worse survival rates in colorectal cancer.
Takeaway
Survivin is a protein that helps cancer cells survive, and its different forms might affect how tumors grow.
Limitations
The study does not provide strong evidence for the role of survivin splice variants in tumorigenesis.
Digital Object Identifier (DOI)
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