Oral Yeast Infections in Tanzanian HIV Patients
Author Information
Author(s): Hamza Omar JM, Matee Mecky IN, Moshi Mainen J, Simon Elison NM, Mugusi Ferdinand, Mikx Frans HM, Helderman Wim H van Palenstein, Rijs Antonius JMM, van der Ven André JAM, Verweij Paul E
Primary Institution: Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
Hypothesis
What is the species distribution and antifungal susceptibility of oral yeast isolates from HIV-infected patients with oropharyngeal candidiasis in Tanzania?
Conclusion
C. albicans was the most frequently isolated species from patients with oropharyngeal candidiasis, and oral yeast isolates from Tanzania showed high susceptibility to antifungal agents.
Supporting Evidence
- C. albicans was isolated from 84.5% of patients.
- Only 5% of isolates were resistant to fluconazole.
- Patients with recurrent candidiasis had reduced susceptibility to azole antifungal agents.
- The study included 292 HIV-infected patients with oropharyngeal candidiasis.
Takeaway
Doctors studied patients with a mouth infection caused by yeast to see which types of yeast were present and how well they responded to medicine. They found that one type of yeast was the most common and that most of them could be treated with the medicine.
Methodology
The study involved isolating clinical oral yeasts from HIV-infected patients and assessing their antifungal susceptibility using broth microdilution methods.
Potential Biases
Potential bias in patient selection and reporting of previous antifungal therapy.
Limitations
The study may not represent all HIV-infected patients in Tanzania due to its specific location and sample size.
Participant Demographics
292 HIV-infected patients, aged 18 to 75 years, with a median age of 34; 74.7% were female.
Statistical Information
P-Value
0.037
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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