Genetic Study of NOS3 and Methamphetamine-Induced Psychosis in Japan
Author Information
Author(s): Okochi T, Kishi T, Ikeda M, Kitajima T, Kinoshita Y, Kawashima K, Okumura T, Tsunoka T, Fukuo Y, Inada T, Yamada M, Uchimura N, Iyo M, Sora I, Ozaki N, Ujike H, Iwata N
Primary Institution: Fujita Health University School of Medicine
Hypothesis
NOS3 may be related to the pathophysiology of methamphetamine-induced psychosis.
Conclusion
NOS3 might not contribute to the risk of methamphetamine-induced psychosis in the Japanese population.
Supporting Evidence
- Endothelial nitric oxide synthase (NOS3) is involved in nitric oxide function in the brain.
- Previous studies suggested a link between nitric oxide and psychotic disorders.
- The study included 183 patients diagnosed with methamphetamine-induced psychosis.
Takeaway
The study looked at whether a gene called NOS3 is linked to a mental health problem caused by methamphetamine, but found no connection.
Methodology
A gene-based case-control study comparing SNPs in NOS3 between patients with methamphetamine-induced psychosis and healthy controls.
Potential Biases
Potential bias due to the selection of subjects from psychiatric hospitals.
Limitations
The small sample size limited the ability to detect associations, and the study did not include rare variant analysis.
Participant Demographics
183 patients with methamphetamine-induced psychosis (151 males, 32 females) and 267 healthy controls (217 males, 50 females), all ethnically Japanese.
Digital Object Identifier (DOI)
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