Dengue Virus Antibodies and Protection
Author Information
Author(s): Odio Camila D., Daag Jedas Veronica, Crisostomo Maria Vinna, Voirin Charlie J., Coello Escoto Ana, Adams Cameron, Dahora Hein Lindsay, Aogo Rosemary A., Mpingabo Patrick I., Raimundi Rodriguez Guillermo, Firdous Saba, Abad Fernandez Maria, White Laura J., Agrupis Kristal An, Deen Jacqueline, de Silva Aravinda M., Ylade Michelle, Katzelnick Leah C.
Primary Institution: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Hypothesis
How do IgG and neutralizing antibody titers relate to protection against dengue virus?
Conclusion
Neutralizing antibodies measured with mature dengue viruses are more strongly associated with protection against dengue than those measured with standard viruses.
Supporting Evidence
- ELISA IgG≥3 was associated with reduced dengue probability relative to naïve children (3% vs. 10%, p=0.007).
- Standard virus PRNT geometric mean titers (GMT) >200 were associated with reduced dengue disease overall (p<0.01).
- High DENV2 and DENV3 titers against either standard or mature viruses protected against the matched serotype (p<0.01).
- Only 2% of cases had mature virus PRNT titers >100 (p<0.001).
Takeaway
This study shows that having the right kind of antibodies can help protect kids from getting sick with dengue.
Methodology
The study followed healthy children in Cebu, Philippines, measuring various antibody levels and their association with dengue risk over five years.
Potential Biases
Potential confounding variables due to the observational design.
Limitations
The study was observational and non-randomized, which may limit generalizability.
Participant Demographics
Children aged 9-14 years from Cebu, Philippines.
Statistical Information
P-Value
0.007
Confidence Interval
95% CI: 5-20
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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