Decreased CD10 Expression in Bone Marrow Neutrophils of HIV Positive Patients
Author Information
Author(s): Annemarie van de Vyver, Eluned Delport, Adele Visser
Primary Institution: University of Pretoria
Hypothesis
To determine the expression level of CD10 on granulocytes in HIV positive patients.
Conclusion
HIV-1 positive patients showed a significant reduction in CD10 expression, with 96.6% of the patients showing expression below 50%.
Supporting Evidence
- 96.6% of HIV-1 positive patients had CD10 expression levels below 50%.
- The average CD10 expression among HIV-1 positive patients was 18.4%.
- CD10 expression was significantly lower in HIV-1 positive patients compared to HIV-1 negative patients.
Takeaway
This study found that most HIV positive patients have very low levels of a specific marker (CD10) on their immune cells, which might affect their ability to fight infections.
Methodology
117 HIV-1 positive and 29 HIV-1 negative patients were included; bone marrow aspirate samples were evaluated for morphological abnormalities and CD10 expression.
Limitations
The presence of concurrent opportunistic infections was not known, and the study excluded patients with certain conditions.
Participant Demographics
Mean age of HIV-1 positive patients was 37 years, and 42 years for HIV-1 negative patients.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website