New Subtype of Aminoglycoside Resistance Gene Found
Author Information
Author(s): Michel Plattner, Maurizio Catelani, Sarah-Lisa Gmür, Maximilian Hartmann, Fatmanur Kiliç, Klara Haldimann, David Crich, Sven N. Hobbie
Primary Institution: Institute of Medical Microbiology, University of Zurich
Hypothesis
Can the phenotypic differentiation of the aac(6′) aminoglycoside resistance gene family lead to the identification of a novel subtype with clinical relevance?
Conclusion
The study identifies a novel subtype IV of the aac(6′) gene family that confers resistance to multiple aminoglycoside antibiotics.
Supporting Evidence
- 21.2% of clinical isolates analyzed contained the aac(6′) resistance gene.
- Subtypes I and II were the most prevalent in Enterobacterales.
- A novel subtype IV was proposed based on the resistance pattern of aac(6′)-Ib11.
Takeaway
Scientists studied a gene that helps bacteria resist antibiotics and found a new type that makes it harder to treat infections.
Methodology
Analyzed resistance gene annotations of 657,603 clinical bacterial isolates and performed phenotypic analysis of cloned aac(6′) genes in E. coli.
Limitations
The study is limited by the database used for analysis and the small number of clinical isolates available for phenotypic assessment.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website