The Role of Exercise in Cancer Treatment
Author Information
Author(s): Buzaglo Glenda B. B., Telles Guilherme D., Araújo Rafaela B., Junior Gilmar D. S., Ruberti Olivia M., Ferreira Marina L. V., Derchain Sophie F. M., Vechin Felipe C., Conceição Miguel S.
Primary Institution: Health Sciences Postgraduate Program, São Francisco University
Hypothesis
Can physical exercise modulate chemokine expression to improve cancer treatment outcomes?
Conclusion
Physical exercise can enhance the immune response against cancer by modulating chemokine expression and improving the tumor microenvironment.
Supporting Evidence
- Exercise increases the infiltration of CD8+ T cells in the tumor microenvironment.
- Regular physical activity reduces pro-inflammatory chemokines associated with tumor growth.
- Exercise enhances the expression of anti-inflammatory chemokines that support immune responses.
- Physical activity improves blood flow and oxygenation in tumors, reducing hypoxia.
- Exercise training can lead to chronic physiological adaptations that favor anti-tumor immunity.
Takeaway
Exercise helps the body fight cancer by making the immune system stronger and changing the environment around the tumor to make it harder for the cancer to grow.
Methodology
The review discusses various studies on the effects of physical exercise on chemokine expression and immune response in cancer.
Limitations
Most studies cited were conducted on cell models and animal subjects, with limited direct evidence from human cancer patients.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website