15-deoxy-delta12,14-prostaglandin J2 attenuates endothelial-monocyte interaction: implication for inflammatory diseases
2008
15-deoxy-delta12,14-prostaglandin J2 and Inflammation
publication
Evidence: high
Author Information
Author(s): Prasad Ratna, Giri Shailendra, Singh Avtar K, Singh Inderjit
Primary Institution: Medical University of South Carolina
Hypothesis
15d-PGJ2 inhibits the adhesion of mononuclear cells to the endothelial cells and thereby attenuates their transmigration.
Conclusion
15d-PGJ2 inhibits inflammation at multiple steps and thus is a potential therapeutic target for various inflammatory diseases.
Supporting Evidence
- 15d-PGJ2 inhibits TNFα induced monocyte adhesion to endothelial cells.
- 15d-PGJ2 downregulates endothelial cell adhesion molecules in a PPARγ independent manner.
- 15d-PGJ2 inhibits the TNFα induced IKK-NF-κB pathway.
Takeaway
15d-PGJ2 is a natural substance that helps reduce inflammation by stopping certain cells from sticking to blood vessels.
Methodology
The study used an in vitro adhesion assay model to examine the effects of 15d-PGJ2 on endothelial-monocyte interactions.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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