Oxidative Stress in Children with Insulin Dependent Diabetes Mellitus
Author Information
Author(s): Ramakrishna Vadde, Jailkhani Rama
Primary Institution: Shri B.M. Patil Medical College, Bijapur and Sri Krishnadevaraya University, Anantapur
Hypothesis
The study aims to evaluate oxidative stress in chronic IDDM patients by estimating lipid peroxidation, protein oxidation, and antioxidant status.
Conclusion
Diabetes leads to increased oxidative stress, resulting in higher protein and lipid oxidation and lower antioxidant levels.
Supporting Evidence
- Diabetic patients showed significantly higher levels of protein carbonyl groups and lipid peroxides.
- Antioxidant levels were decreased in diabetic patients compared to healthy controls.
- Hyperglycemia was associated with increased oxidative stress markers.
- Diabetic children had a 4-fold increase in lipid peroxidation compared to healthy controls.
Takeaway
Kids with diabetes have more damage from bad stuff in their bodies called free radicals, which makes them less healthy.
Methodology
The study involved 35 children (15 with IDDM and 20 healthy controls) who were tested for lipid peroxidation, protein oxidation, and antioxidant levels.
Limitations
The study only included children and may not be generalizable to adults.
Participant Demographics
Children aged 5-20 years, with 15 having IDDM and 20 being healthy controls.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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