Protective Effects of Sesame Peptides on Gastric Mucosal Injury
Author Information
Author(s): Yuan Yutong, Wang Xinyi, Ling Nan, Zhou Jingxuan, Zhao Lei, Ji Baoping, Zhou Feng, Zhao Liang
Primary Institution: China Agricultural University
Hypothesis
This study aimed to investigate the protective effects and defense mechanisms of a sesame meal protein hydrolysate against ethanol-induced acute gastric mucosal injury in mice.
Conclusion
Sesame peptides significantly inhibited gastric mucosal injury caused by ethanol in mice, suggesting their potential as a natural protective agent.
Supporting Evidence
- Sesame peptides reduced the levels of ALT and AST in serum, indicating liver protection.
- Inflammatory markers like TNF-α and IL-1β were significantly reduced in the sesame peptide groups.
- Antioxidant activity was enhanced in gastric tissues treated with sesame peptides.
- Histopathological analysis showed less damage in gastric mucosa of mice treated with sesame peptides compared to the control group.
Takeaway
Sesame peptides can help protect the stomach from damage caused by alcohol, making them a good natural remedy.
Methodology
Mice were divided into groups and given sesame peptides or omeprazole for 21 days, followed by ethanol to induce gastric injury, with various biochemical and histopathological assessments performed.
Limitations
The study was conducted on mice, and results may not directly translate to humans.
Participant Demographics
Male Kunming mice, aged 4 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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