Uterine Fibroid Symptom and Quality of Life Questionnaire Responsiveness
Author Information
Author(s): Harding Gale, Coyne Karin S, Thompson Christine L, Spies James B
Primary Institution: United BioSource Corporation
Hypothesis
The study aims to evaluate the responsiveness of the Uterine Fibroid Symptom and Health-Related Quality of Life Questionnaire (UFS-QOL) in patients treated for uterine fibroids.
Conclusion
The UFS-QOL is responsive to treatment for uterine fibroids and is a useful outcome measure for uterine-sparing uterine fibroid treatments.
Supporting Evidence
- The UFS-QOL showed significant improvements in symptom severity and health-related quality of life scores.
- Effect sizes for UFS-QOL subscales ranged from 0.74 to -1.9, indicating high responsiveness.
- Patients who reported improvement in symptoms had significantly greater change scores in UFS-QOL.
- All UFS-QOL subscales demonstrated large effect sizes from baseline to month 6.
Takeaway
This study shows that a special questionnaire can help doctors understand how well treatments for uterine fibroids are working by asking patients about their symptoms and quality of life.
Methodology
A post-hoc analysis of patients treated with MRI-guided focused ultrasound thermal ablation for uterine fibroids, assessing UFS-QOL and SF-36 at baseline and follow-ups.
Limitations
The study lacked a placebo group, making it difficult to rule out the placebo effect.
Participant Demographics
Mean age was 45 years; 79% were Caucasian.
Statistical Information
P-Value
p < 0.0001
Statistical Significance
p < 0.0001
Digital Object Identifier (DOI)
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