Herbal-Leucine Mix and Cartilage Health
Author Information
Author(s): Akhtar Nahid, Miller Mark JS, Haqqi Tariq M
Primary Institution: MetroHealth Medical Center, Case Western Reserve University
Hypothesis
The study investigates the anti-inflammatory and chondroprotective potential of a Herbal-Leucine mixture on cartilage degradation and inflammatory gene expression in human chondrocytes.
Conclusion
The Herbal-Leucine mixture may protect cartilage and reduce inflammation in arthritis by altering gene expression in chondrocytes.
Supporting Evidence
- HLM significantly inhibited the expression of iNOS and production of nitric oxide in IL-1β-stimulated OA chondrocytes.
- HLM reduced the levels of MMP-9 and MMP-13 in chondrocytes stimulated with IL-1β.
- HLM increased the expression of ACAN and COL2A1 in OA chondrocytes.
- HLM inhibited the IL-1β-induced release of glycosaminoglycans from cartilage explants.
Takeaway
This study shows that a mix of herbs and an amino acid can help protect joints and reduce inflammation, which is good for people with arthritis.
Methodology
Primary OA chondrocytes were treated with a Herbal-Leucine mixture and stimulated with IL-1β, followed by analysis of gene expression and protein production.
Limitations
The study was conducted in vitro, and results may not fully translate to in vivo conditions.
Participant Demographics
Mean age of participants was 60.6 years, all diagnosed with osteoarthritis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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