Effects of Lactiplantibacillus plantarum HM-P2 on Gut Health During Pregnancy
Author Information
Author(s): Liu Bin, Zhang Zhenzhen, Zhao Junying, Li Xianping, Wang Yaru, Liu Lu, Qiao Weicang, Chen Lijun
Primary Institution: National Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co. Ltd.
Hypothesis
Can the probiotic Lactiplantibacillus plantarum HM-P2 influence gestational health by modulating the gut microbiome and microbial metabolism?
Conclusion
The study found that Lactiplantibacillus plantarum HM-P2 positively influenced gut microbiome composition and increased beneficial metabolites in gestational mice.
Supporting Evidence
- L. plantarum HM-P2 increased the top crypt depth of the colon in gestational mice.
- Microbes such as L. reuteri and Gemmiger were up-regulated in the HM-P2 group.
- HM-P2 significantly promoted the contents of intestinal caproic acid and bile acids.
- Serotonin levels were increased in the HM-P2 group compared to controls.
Takeaway
This study shows that a special probiotic from human milk can help make the tummies of pregnant mice healthier.
Methodology
The study used fecal microbiome transplant techniques in germ-free mice to assess the effects of the probiotic on gut health.
Limitations
The study had a limited number of germ-free mice and did not investigate the effects on offspring health.
Participant Demographics
Nine healthy gestational donors were recruited for fecal sample collection.
Statistical Information
P-Value
0.032
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website