Sodium butyrate enhances STAT 1 expression in PLC/PRF/5 hepatoma cells and augments their responsiveness to interferon-α
1999
Sodium Butyrate and Interferon-α in Liver Cancer Treatment
publication
Author Information
Author(s): Hung W-C, Chuang L-Y
Primary Institution: Kaohsiung Medical College
Hypothesis
Can sodium butyrate enhance the anti-tumour effect of interferon-α in hepatoma cells?
Conclusion
Sodium butyrate enhances the anti-tumour effect of interferon-α in hepatoma cells.
Supporting Evidence
- Sodium butyrate specifically activated STAT1 gene expression.
- Co-treatment with sodium butyrate and interferon-α led to G1 growth arrest in hepatoma cells.
- Down-regulation of cyclin D1 and up-regulation of p21WAF-1 were observed.
- Internucleosomal DNA fragmentation, a hallmark of apoptosis, was detected after treatment.
Takeaway
Sodium butyrate helps make liver cancer cells more responsive to a treatment called interferon-α, which can help fight cancer.
Methodology
The study investigated the effects of sodium butyrate on STAT protein expression and its combination with interferon-α in hepatoma cells.
Digital Object Identifier (DOI)
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