Genetics of Ischaemic Stroke in Non-Europeans
Author Information
Author(s): Ariyaratnam Roshan, Casas Juan P, Whittaker John, Smeeth Liam, Hingorani Aroon D, Sharma Pankaj
Primary Institution: Imperial College London
Hypothesis
Are the genetic risk factors for ischaemic stroke the same in persons of non-European descent as in those of European descent?
Conclusion
Genetic associations for ischaemic stroke among non-Europeans are similar to those found for Europeans.
Supporting Evidence
- Three of the eight candidate genes studied were associated with ischaemic stroke.
- The angiotensin I converting enzyme (ACE) gene variant showed a significant odds ratio in the Chinese population.
- The study included a large sample size of approximately 32,500 individuals.
- Genetic effects were found to be similar across different ethnic groups.
- Publication bias may have influenced the observed genetic effects.
Takeaway
This study looked at how genes affect stroke risk in people from different backgrounds and found that the same genes seem to be involved for both Europeans and non-Europeans.
Methodology
A systematic review and meta-analysis of genetic association studies in stroke among non-Europeans, analyzing odds ratios and confidence intervals.
Potential Biases
There is a risk of small-study bias affecting the results.
Limitations
The study is limited by the smaller number of gene variants evaluated and potential publication bias.
Participant Demographics
Mainly Chinese, Japanese, and Korean individuals.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI 1.23–2.93 for ACE, 95% CI 0.90–1.56 for MTHFR, 95% CI 1.52–3.13 for APOE
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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