USING FUNCTIONAL BRAIN IMAGING DATA TO PREDICT FALLS IN OLDER ADULTS WITH MULTIPLE SCLEROSIS
2024

Predicting Falls in Older Adults with Multiple Sclerosis

Sample size: 81 publication Evidence: moderate

Author Information

Author(s): Holtzer Roee

Primary Institution: Yeshiva University and Albert Einstein College of Medicine

Hypothesis

Can brain hemodynamic responses during dual-task-walking predict falls in older adults with multiple sclerosis?

Conclusion

Higher brain oxygen levels during dual-task walking may help prevent falls in older adults with relapsing-remitting multiple sclerosis.

Supporting Evidence

  • Higher HbO under dual-task-walking was significantly associated with a reduction in falls for relapsing-remitting MS.
  • Faster stride velocity under dual-task-walking was significantly associated with a reduction in falls for progressive MS.

Takeaway

This study found that how the brain works while walking can help predict if older adults with multiple sclerosis will fall.

Methodology

Participants completed a dual-task-walking paradigm while brain activity was measured using functional-near-infrared-spectroscopy.

Participant Demographics

Participants included 53 with relapsing-remitting MS and 28 with progressive MS, with a mean age around 65 years.

Statistical Information

P-Value

p=.004

Confidence Interval

95%CI=.284 to.785

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1093/geroni/igae098.0147

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