Effects of Albumin and Paracentesis on Kidney Function in Cirrhotic Patients
Author Information
Author(s): Umgelter Andreas, Reindl Wolfgang, Wagner Katrin S, Franzen Michael, Stock Konrad, Schmid Roland M, Huber Wolfgang
Primary Institution: Medizinische Klinik und Poliklinik der Technischen Universität München
Hypothesis
This study investigates the short-term effects of paracentesis on haemodynamics and kidney function in volume resuscitated patients with hepato-renal syndrome.
Conclusion
Paracentesis with parameter-guided fluid substitution and maintenance of central blood volume may improve renal function and is safe in the treatment of ICU patients with hepato-renal failure.
Supporting Evidence
- Mean arterial pressure and central venous pressure remained unchanged after albumin infusion.
- Creatinine clearance increased significantly after paracentesis.
- Paracentesis resulted in a substantial decrease in intra-abdominal pressure.
Takeaway
Doctors used a procedure called paracentesis to help patients with liver problems and kidney issues feel better by reducing pressure in their bellies.
Methodology
Nineteen consecutive cirrhotic patients with hepato-renal syndrome were studied, with haemodynamic parameters and renal function analyzed before and after plasma expansion and paracentesis.
Limitations
The study lacks a control group, making it difficult to prove a causal relationship between paracentesis and improvement in renal function.
Participant Demographics
17 male, 2 female; mean age 59 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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