Implementing a system of quality-of-life diagnosis and therapy for breast cancer patients: results of an exploratory trial as a prerequisite for a subsequent RCT
2008

Quality of Life Diagnosis and Therapy for Breast Cancer Patients

Sample size: 170 publication Evidence: moderate

Author Information

Author(s): Klinkhammer-Schalke M, Koller M, Ehret C, Steinger B, Ernst B, Wyatt J C, Hofstädter F, Lorenz W

Primary Institution: Tumor Center Regensburg e.V.

Hypothesis

Are there differences between implementation sample and general population, and what is the relationship between patient and practitioner assessments of quality of life?

Conclusion

The study successfully implemented a quality-of-life system for breast cancer patients, revealing significant discrepancies between patient-reported and clinician-assessed quality of life.

Supporting Evidence

  • 74% of coordinating practitioners adhered to the care pathway.
  • Patients reported significantly lower quality of life scores compared to doctors' assessments.
  • The study established a 50-point cutoff for distinguishing between healthy and diseased quality of life.

Takeaway

This study helped doctors understand how breast cancer patients feel about their quality of life, showing that patients often feel worse than doctors think.

Methodology

The study involved an exploratory trial with patient and clinician assessments of quality of life, using questionnaires and statistical analysis to compare results.

Potential Biases

There is a risk of bias in patient selection by clinicians, favoring younger patients.

Limitations

The study may have selection bias as older patients were underrepresented in the sample.

Participant Demographics

Participants included 170 breast cancer patients, with a median age of 58 years, and a mix of professional and family statuses.

Statistical Information

P-Value

p<0.001

Confidence Interval

95% C.I. 0.37–0.66

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1038/sj.bjc.6604505

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